TABLE 1.
The 50% inhibitory concentration values of T-2307 against respiratory chain complexes in Saccharomyces cerevisiae, Candida albicans, and bovine heart mitochondriaa
| Source | IC50 (μM) ± SD |
||
|---|---|---|---|
| S. cerevisiae | C. albicans | Bovine heart | |
| Complex I | Nonexistence | 344 ± 32 | >3,000 |
| Complex II | 755 ± 73 | >3,000 | Not determined |
| Complex II + III | 271 ± 37 | 220 ± 55 | >3,000 |
| Complex IV | 149 ± 23 | 225 ± 23 | >3,000 |
a
The values represent means and standard deviations of pooled data from two independent experiments, each performed in triplicate in S. cerevisiae and C. albicans mitochondria and 6 to 8 times in bovine heart mitochondria.