FIG 1.

MEDI3902 prophylaxis and treatment improves survival outcome in a rabbit bloodstream infection model. (A to D) Comparisons of Kaplan-Meier survival curves (A), log₁₀ CFU/lung (B), log₁₀ CFU/spleen (C), and log₁₀ CFU/kidneys (D) for rabbits administered intravenously with 15 mg/kg MEDI3902 at 24 h before infection (hbi) (n = 6), 15 mg/kg MEDI3902 at 1 h postinfection (n = 6), and 15 mg/kg control IgG at 24 h before infection (n = 6) with strain 6077. A one-sided log rank (Mantel-Cox) test was used to evaluate survival of control IgG- versus MEDI390-treated animals. Bacterial densities for animals pretreated with 15 mg/kg control IgG were compared to those pretreated or treated with 15 mg/kg MEDI3902 by nonparametric one-way analysis of variance (ANOVA) with Kruskal-Wallis test, followed by Dunn’s multiple-comparison test. Filled symbols represent data from dead animals, and open symbols represent data from surviving animals that were euthanized at 96 h postinfection.