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Tolerance of Aspergillus fumigatus to caspofungin. (A) Microscopic observation of A. fumigatus isolates after 24 h growth at 37°C in liquid RPMI 1640 medium in the absence of drug and in the presence of caspofungin 1 μg/ml. (B) Visualization of the paradoxical effect of caspofungin on A. fumigatus isolates. Pictures were taken after 5 days of growth at 37°C on glucose minimal medium agar plates supplemented with caspofungin at increasing concentrations (0, 1, 2, and 4 μg/ml).
