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Relationships between change in log10 CFU from baseline at 24 hours for S. pneumoniae ATCC 10813 and each of free-drug plasma (A) and total-drug ELF (B) PK/PD indices. Each symbol represents the change in log10 CFU from baseline in the lungs of mice at 24 hours. The horizontal line represents the bacterial burden at the start of therapy. q3h, q6h, q12h, and q24h represent regimens of every 3, 6, 12, and 24 hours, respectively.
