TABLE 3.

Parameter estimates and associated percent standard errors for the Hill-type models describing the relationship between the free-drug plasma or total-drug ELF AUC/MIC ratio and change in log₁₀ CFU from baseline for the 24 hour time point for S. pneumoniae^a

Parameter	Parameter estimates and associated percent standard errors (%SE)
	Free-drug plasma	Total-drug ELF
Econ	0.444 (0.337)	0.496 (0.324)
Emax	7.59 (0.669)	7.45 (0.638)
EC50	0.991 (6.97)	0.507 (5.72)
Hill	27.2 (12.3)	232 (9.58)
r2	0.834	0.833

^aBased on data pooled from mice infected with S. pneumoniae ATCC 10813, CDC 1329, and CDC 1396. Econ is the change in log₁₀ CFU at 24 hours from baseline when no drug is administered; E_max is the maximum change in log₁₀ CFU from baseline at 24 hours relative to Econ; EC₅₀ is the AUC/MIC ratio at which there is half-maximal effect; Hill is the Hill coefficient; %SE is % standard error.