TABLE 1.

PAE in S. pneumoniae R6 and R6 ΔspxB^a

Strain	PAE (h) (P value) for:b
	LVX (×MIC)		MXF (×MIC)
	2.5	10	2.5	10
R6	2.05 ± 0.10	3.23 ± 0.45	0.87 ± 0.1	2.41 ± 0.29
R6 ΔspxB	1.18 ± 0.13 (0.0008)	1.53 ± 0.06 (0.003)	0.43 ± 0.15 (0.015)	1.53 ± 0.12 (0.008)

^aBacteria grown to 10⁸ CFU/ml were exposed to the drugs for 1 h. Treatment finished by 1/1,000 dilution with fresh medium. R6 ΔspxB has a deletion in spxB (20).

^bPAE was measured by viable count method. Results are the averages ± SDs from three independent replicates. P values are for the differences between R6 and R6 ΔspxB. The MICs of LVX and MXF for both strains were 1 μg/ml and 0.06 μg/ml, respectively.