TABLE 3.

PK/PD of fosfomycin in murine pyelonephritis due to E. coli after a 24-h treatment^a

Strain	FOS MIC (μg/ml)	FOS AUC0–24/MIC		Start-of-treatment control mice		FOS-treated mice
		Plasma	Kidney	Median (range) log10 CFU count/g of kidneys	No. of sterile mice/total no. of mice tested	Median (range) log10 CFU count/g of kidneys	No. of sterile mice/total no. of mice tested
CFT073	1	357.1	614.5	3.9 (1.9–5.3)	0/11	2.0 (1.8–5.1)	4/9
B56	8	44.6	76.8	3.0 (2.5–6.5)	0/11	1.8 (1.8–2.8)	4/10
B175	32	11.2	19.2	3.4 (2.1–7.0)	0/11	1.9 (1.8–4.9)	4/10
MUT2	64	5.6	9.6	3.7 (2.2–6.8)	0/12	1.9 (1.8–5.5)	5/10
C05	128	2.8	4.8	3.7 (2.3–4.9)	0/8	2.7 (1.9–4.1)	3/10
C114	256	1.4	2.4	3.7 (1.8–5.8)	0/14	1.9 (1.8–5.7)	6/10

^aFOS, fosfomycin. The median bacterial loads in kidney were 3.7 log₁₀ CFU/g (range, 1.8, 7.0 log₁₀ CFU/g) in the start-of-treatment control mice and 1.9 log₁₀ CFU/g (range, 1.8, 5.7 log₁₀ CFU/g) in the fosfomycin-treated mice (P < 10⁻⁶). The lower limit of detection was 1.8 log₁₀ CFU/g of kidney.