From top to bottom: Axial FLAIR image in a 34-year-old woman; Axial FLAIR image in a 32-year-old man; Coronal FLAIR image in a 39-year-old woman. All cases are relapsing-remitting MS. FLAIR images are shown for the registered time point 1 (TP1) and the respective time point 2 (TP2). Results from algorithm before (LeMan) and after (LeMan-PV) applying the partial volume model using the conventional protocol are shown in the 3rd-4th and 5th–6th columns, respectively. The output of Leman is a binary mask and the output of LeMan-PV is a concentration map. Examples of new, stable, shrunken, and enlarged WM lesions are indicated with red, pink, blue, and yellow arrows, respectively. Patches of the zoomed area of the different lesion categories in each image contrast (MPRAGE, MP2RAGE, FLAIR, and DIR) are shown at the bottom. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)