Table 2.
Annualized rates of change over time for select clinical measures
| PAA | AOS+PAA | P-values (FDR P-values) | |
|---|---|---|---|
| Visit interval, years | 1.04 (0.98, 1.25) | 1.29 (1.10, 1.74) | 0.116 (0.213) |
| WAB-AQ | −11.35 (−16.38, −7.65) | −3.99 (−6.97, −0.26) | 0.012 (0.05) |
| WAB-fluency | −1.93 (−2.23, −1.54) | −0.98 (−1.44, −0.85) | 0.022 (0.059) |
| WAB-repetition | −0.73 (−1.40, −0.10) | −0.10 (−0.87, 0.12) | 0.232 (0.328) |
| WAB-spontaneous speech | −3.17 (−4.18, −2.44) | −0.98 (−2.62, 0.00) | 0.022 (0.059) |
| WAB-information content | −1.04 (−2.04, −0.76) | 0.00 (−1.75, 0.00) | 0.074 (0.155) |
| WAB-praxis | −1.56 (−3.48, 1.02) | −5.90 (−14.53, −3.49) | 0.019 (0.059) |
| Aphasia severity | 0.76 (0.54, 0.91) | 0.00 (0.00, 0.46) | 0.029 (0.067) |
| TT | −4.62 (−6.38, −4.08) | −1.20 (−2.79, −0.24) | 0.006 (0.049) |
| BNT | −2.01 (−2.88, −1.85) | 0.00 (−1.28, 0.00) | 0.009 (0.049) |
| NAT | −3.02 (−3.42, −1.34) | −1.40 (−1.58, 0.02) | 0.268 (0.351) |
| ASRS | −0.85 (−1.01, 0.00) | 1.97 (1.59, 3.80) | 0.002 (0.046) |
| NVOA | −6.12 (−11.58, −3.27) | −5.73 (−7.50, −2.61) | 0.664 (0.734) |
| Letter fluency | −4.20 (−4.58, −2.54) | −3.94 (−4.29, −2.91) | 0.836 (0.843) |
| Action fluency | −2.56 (−3.34, −0.50) | −1.97 (−2.81, −0.85) | 0.607 (0.708) |
| MSD | −0.46 (−1.04, 0.00) | −1.15 (−1.73, −0.60) | 0.094 (0.179) |
| FBI | −0.67 (−4.02, 4.27) | 3.28 (1.50, 6.55) | 0.234 (0.328) |
| MDS-UPDRS III | −1.04 (−2.39, 0.00) | 12.73 (3.94, 17.95) | 0.007 (0.049) |
| CDR | 0.00 (0.00, 0.67) | 0.53 (0.34, 5.10) | 0.173 (0.279) |
| MoCA | −5.20 (−9.73, −2.01) | −1.84 (−7.82, 0.00) | 0.153 (0.268) |
| FAB | −2.08 (−3.44, −1.52) | −1.75 (−4.30, −0.46) | 0.843 (0.843) |
| NPI-Q | 0.00 (−2.26, 1.56) | 0.70 (0.00, 3.18) | 0.29 (0.359) |
Bold values were significant after FDR correction for multiple comparisons.
Values are shown as median (q1, q3).
Only select clinical variables with the most complete longitudinal testing are shown.
ASRS = Apraxia of Speech Rating Scale; BNT = Boston Naming Test; CDR = Clinical Dementia Rating; FAB = Frontal Assessment Battery; FBI = Frontal Behavioral Inventory; MoCA = Montreal Cognitive Assessment; MSD = Motor speech disorder rating; NAT = Northwestern Anagram Test; NPI-Q = Neuropsychiatric Inventory Questionnaire; NVOA = Non-Verbal Oral Apraxia rating; TT = Token Test.