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. 2019 Jul 19;10:1574. doi: 10.3389/fimmu.2019.01574

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Copyright © 2019 Wang, Zhang and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synergistic effect of three combined strategies by targeting complement/C3aR /C5aR1/IL-10 pathway and other treatment modalities. The three combined strategies were shown as follows: (1) dual blockade of complement signaling and immune checkpoint receptor PD-1; (2) complement signaling blockade and chemotherapy; (3) the clinical use of pegylated rhIL-10 with anti-PD-1 antibody.