Table 3. PTNB Accuracy for Diagnosis of Malignancy Stratified by Lesion Size, Lesion Type, Biopsy Needle, and Guiding Modality.
| Factor | Accuracy | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|
| Lesion size (cm) | |||||
| ≤ 1.0 | 88.2 (83.8–91.7) [247/280] | 87.1 (81.4–91.6) [162/186] | 90.4 (82.6–95.5) [85/94] | 98.8 (95.7–99.9) [162/164] | 84.2 (75.6–90.7) [85/101] |
| 1.1–2.0 | 87.3 (85.8–88.7) [1860/2130] | 88.6 (86.9–90.2) [1346/1519] | 84.1 (81.0–86.9) [514/611] | 98.8 (98.0–99.3) [1346/1363] | 82.6 (79.4–85.5) [514/622] |
| 2.1–3.0 | 91.6 (90.5–92.7) [2224/2427] | 93.4 (92.2–94.5) [1716/1837] | 86.1 (83.0–88.8) [508/590] | 99.2 (98.6–99.6) [1716/1730] | 87.7 (84.8–90.3) [508/579] |
| > 3.0 | 92.8 (92.1–93.6) [4220/4545] | 93.9 (93.1–94.7) [3498/3725] | 88.0 (85.6–90.2) [722/820] | 99.5 (99.2–99.7) [3498/3516] | 83.3 (80.6–85.7) [722/867] |
| Lesion type | |||||
| Solid | 91.4 (91.0–91.9) [8206/8981] | 92.8 (92.2–93.4) [6418/6914] | 86.5 (85.0–87.9) [1788/2067] | 99.3 (99.0–99.5) [6418/6466] | 85.1 (83.5–86.6) [1788/2100] |
| Subsolid | 86.1 (82.3–89.3) [346/402] | 86.1 (82.1–89.6) [304/353] | 85.7 (72.8–94.1) [42/49] | 99.0 (97.2–99.8) [304/307] | 60.0 (47.6–71.5) [42/70] |
| Lesion depth (cm) | |||||
| 0 | 91.6 (90.4–92.6) [2216/2420] | 93.0 (91.7–94.1) [1710/1839] | 87.1 (84.1–89.7) [506/581] | 99.2 (98.6–99.6) [1710/1724] | 85.2 (82.1–87.9) [506/594] |
| 0.1–1.0 | 90.0 (88.3–91.6) [1190/1322] | 91.6 (89.7–93.2) [926/1011] | 84.9 (80.4–88.7) [264/311] | 98.9 (98.0–99.5) [926/936] | 82.2 (77.6–86.3) [264/321] |
| 1.1–2.0 | 90.7 (89.3–92.0) [1690/1863] | 93.1 (91.7–94.4) [1340/1439] | 82.5 (78.6–86.0) [350/424] | 99.1 (98.5–99.5) [1340/1352] | 86.0 (82.2–89.2) [350/407] |
| 2.1–3.0 | 91.8 (90.3–93.1) [1435/1563] | 92.8 (91.2–94.2) [1147/1236] | 88.1 (84.1–91.4) [288/327] | 99.2 (98.5–99.6) [1147/1156] | 84.0 (79.6–87.7) [288/343] |
| > 3.0 | 91.2 (90.0–92.4) [2022/2216] | 91.8 (90.4–93.0) [1600/1743] | 89.2 (86.1–91.9) [422/473] | 99.6 (99.2–99.9) [1600/1606] | 83.6 (80.0–86.7) [422/505] |
| Biopsy needle | |||||
| FNA only | 86.1 (85.0–87.2) [3612/4194] | 89.4 (88.3–90.5) [2890/3231] | 75.0 (72.1–77.7) [722/963] | 98.7 (98.2–99.1) [2890/2928] | 80.9 (78.2–83.5) [722/892] |
| CNB or combined | 95.2 (94.6–95.8) [4941/5190] | 94.9 (94.2–95.6) [3833/4037] | 96.1 (94.8–97.1) [1108/1153] | 99.7 (99.4–99.8) [3833/3846] | 86.7 (84.7–88.5) [1108/1278] |
| Guiding modality | |||||
| Fluoroscopy | 87.4 (86.0–88.6) [2211/2531] | 90.5 (89.2–91.7) [1906/2106] | 71.8 (67.2–76.0) [305/425] | 98.8 (98.2–99.2) [1906/1930] | 77.2 (72.8–81.3) [305/395] |
| CT | |||||
| Conventional CT | 93.3 (92.2–94.2) [2374/2545] | 94.8 (93.7–95.7) [1855/1957] | 88.3 (85.4–90.8) [519/588] | 99.5 (99.1–99.8) [1855/1864] | 87.2 (84.3–89.8) [519/595] |
| CTF | 78.3 (75.3–81.0) [655/837] | 80.1 (76.8–83.2) [512/639] | 72.2 (65.4–78.3) [143/198] | 98.8 (97.5–99.6) [512/518] | 65.9 (59.2–72.2) [143/217] |
| CBCT | 95.6 (94.8–96.3) [3227/3376] | 95.6 (94.7–96.4) [2379/2488] | 95.5 (93.9–96.8) [848/888] | 99.5 (99.2–99.8) [2379/2390] | 89.8 (87.7–91.7) [848/944] |
| Ultrasonography | 90.5 (82.8–95.6) [86/95] | 91.0 (82.4–96.3) [71/78] | 88.2 (63.6–98.5) [15/17] | 98.6 (92.5–100.0) [71/72] | 78.9 (54.4–93.9) [15/19] |
| Total | 91.1 (90.6–91.7) [8553/9384] | 92.5 (91.9–93.1) [6723/7268] | 86.5 (85.0–87.9) [1830/2116] | 99.2 (99.0–99.4) [6723/6774] | 84.3 (82.7–85.8) [1830/2170] |
Unless otherwise specified, data represent percentages, % (95% CI) [numerator/denominator]. CI = confidence interval, NPV = negative predictive value, PPV = positive predictive value