Figure 2.

Direct comparisons of cells migrating in 1D, 2D and 3D models in vitro. Many specific cell biological behavioural features of fibroblasts migrating within a fibronectin‐rich 3D cell‐derived matrix are mimicked by migration of these cells on fibronectin‐coated 1D lines, but not migration on 2D glass substrates coated with fibronectin or with serum proteins. Figure re‐drawn from Doyle et al28 [Colour figure can be viewed at wileyonlinelibrary.com]