TABLE 2.

Comparison of tissue K_P values for DEX determined by different methods Values are listed as the mean ± S.D.

Tissue (Sex)	In Vivo KP	fu,t (in vitro)	In Vitro KP	Method 1	Method 2	Method 3
Liver (male)	5.5 ± 0.3a	0.050 ± 0.001	3.6 ± 0.5c	1.3	0.7	0.6
	4.8 ± 0.5b	0.068 ± 0.001	2.6 ± 0.4d
Liver (female)	—	0.059 ± 0.004	3.0 ± 0.5c
		0.070 ± 0.003	2.5 ± 0.4d
Lung (male)	0.53 ± 0.02a	0.115 ± 0.006	1.5 ± 0.3d	1.4	0.8	0.6
	0.43 ± 0.05b
Muscle (male)	0.50 ± 0.0a	0.236 ± 0.03	0.74 ± 0.1d	0.9	0.6	0.34
	0.49 ± 0.04b

^aSubcutaneous injection.

^bSubcutaneous infusion.

^cLow DEX concentration (1 μg/ml).

^dHigh DEX concentration (10 μg/ml).