Fig. 8.

Effects of mutant number and position. Wild-type α7 and α7M254L were coexpressed alone or at various ratios such that the total RNA injected was held constant. Plotted are the average peak currents to two initial ACh controls (left axis) and the averaged normalized net charge responses potentiated by the coapplication of 1 µM (racemic) TQS (right axis). There were no significant differences among the ACh responses (one-way ANOVA). When the percentage of wild-type RNA was less than 50%, the potentiation was less (P < 0.05) than with 100% α7 wild type.