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. 2019 May 2;21(6):591–601. doi: 10.1016/j.neo.2019.04.003

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© 2019 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Differentially regulated genes and pathways between the HPV16 subtypes. (A) Heatmap of significant differentially expressed genes between the subtypes with different enrichment in the predicted epithelial-mesenchymal transition status. (B) The volcano plot shows representative genes within interested pathways. (C) Kyoto Encyclopedia of Genes and Genomes analysis demonstrated that the immune-related pathway and TNF signaling were enriched in the HPV16-IMM subtype, whereas the Wnt signaling was enriched in the HPV16-KRT subtype. (E) Heatmap of the enrichment level calculated by single-sample gene set enrichment analysis for interested pathways derived from GSEA and their corresponding GSEA plots in (F).