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. 2019 Jul 19;10:1703. doi: 10.3389/fimmu.2019.01703

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Copyright © 2019 Moon and Powis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NKD and viral induced cancer. NKD results in reduced number of NK cells (11) and downregulation of activating receptors against oncogenic viruses (24). This increases the susceptibility to EBV and HPV infections which subsequently progress into cancer (27–31). In addition, NKD compromises cytotoxicity against viruses during the infection allowing viral genes to be transfected into infected cells which transform into cancerous cells (23, 25). The arrows indicate the increased risk of developing conditions on the box that it is pointing to.