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. 2019 Jul 19;10:1703. doi: 10.3389/fimmu.2019.01703

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Copyright © 2019 Moon and Powis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of association between NKD and cancer. Arrows indicate association between the box it is emerging from and the box it is pointing to. GATA2, MCM4, IRF8, RTEL1, and FCGR3A are the genes responsible for NKD. GATA2 increases the risk of MDS-AML MCM4 is associated with increased NDA instability. NKD is associated with increased susceptibility to MDS-AML and some oncogenic viral infections. NKD has been observed in other solid tumors and breast cancer although association on between them is unknown.