Table 5.
Highest ranked SAPH-ire PTM sites. The highest ranked SAPH-ire PTM sites along with the predominant PTMs identified and what is known about these PTMs from the literature.
| SAPH-ire FPx RANK | MAP ID (IPR001424) | Residue in Mouse (P08228) | Predominant PTM | SAPH-ire Score (rel to max) | What is Already Known about this PTM in Different Species | Reference |
|---|---|---|---|---|---|---|
| 1 | 129 | Ser98 | Phos. | 100 | phosphorylation promotes SOD1 nuclear localization to maintain genomic stability; kinase is Dun1 | Tsang, 2014 |
| 2 | 142 | Ser111 | Phos. | 35 | ||
| 3 | 138 | Ser107 | Phos. | 24 | ||
| 4 | 167 | Lys128 | Ac./Ub./Gly. | 19 | glycation causes enzymatic deactivation | Fujii, 1996 |
| 5 | 133 | Arg102 (human Ser102) | Phos. | 18 | ||
| 6 | 155 | Lys122 | Ac./Su./Ub./Gly. | 16 | succinylation inactivates ROS scavenging activity; desuccinylated by SIRT5 | Lin, 2013 |
| acetylation/succinylation inhibit SOD1's anti-respiratory activity, succinyl-mimetics cause decreased growth and less healthy mitochondria in HCT116 cells, does not affect ROS scavenging activity | Banks, 2017 | |||||
| acetylated SOD1 found in distinct regions of adult central nervous system | Kaliszewski, 2016 | |||||
| 7 | 136 | Ser105 | Phos. | 14 |