Table 2: Results of Studies of Curcumin using Drug Delivery Systems to Increase Bioavailability.

Study	Formulation	Advantage	Application	Outcome
El-Naggar et al. 2010[64]	Biodegradable curcumin encapsulated in polylactide-poly(ethylene glycol) copolymer nanoparticles	Better solubility and stability	Streptozotocin-induced diabetic rats	Enhanced the suppressive effect on markers of hepatitis and oxidative stress
Karri et al. 2016[65]	Curcumin in chitosan nanoparticles impregnated into a collagen-alginate scaffold	Better solubility and stability Controlled release Prevention from rapid clearance	Streptozotocin-induced diabetic rats	Promoted wound healing
Hu et al. 2018[66]	Inhalable curcumin-loaded poly(lactic-co-glycolic) acid large porous microparticles	Suitable aerodynamic diameters for inhalation Prevention from phagocytosis	Rat pulmonary fibrosis models	Enhanced antifibrotic activity
Qiao et al. 2017[67]	Amphiphilic curcumin polymer	Better solubility and stability Targeting for colonic reducing environment	Dextran sulphate sodium-induced mouse model of inflammatory bowel disease	Suppressed the progress of inflammation in the colon
Young et al. 2014[68]	Nano-emulsion curcumin	Better solubility Protection from metabolism	Lipopolysaccharide-induced acute inflammation model mice	Suppressed lipopolysaccharide-induced blood monocyte accumulation
Li et al. 2019[69]	E-selectin-modified atorvastatin calcium-and curcumin-loaded liposome	Targeted for endothelial cells Co-delivery	ApoE-/- mice	Suppressed atherosclerosis
Funamoto et al. 2016[40]	Curcumin dispersed with colloidal nanoparticles	Better stability and solubility	People with mild chronic obstructive pulmonary disease	Suppressed an increase in alpha1-antitrypsin LDL