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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Acta Biomater. 2019 May 3;94:204–218. doi: 10.1016/j.actbio.2019.04.057

Figure 7.

Figure 7.

Scaled-up prototype of crosslinked PCLTA 900 in the degenerating pig sub-retinal space 30 days after transplantation. Representative en face (A) and horizontal B-scan (B) optical coherence tomographs (green line in A indicates cross-sectional plane shown in B) of the post-mortem Pro23His pig eye show placement of the transplanted polymer (border indicated with arrows in A and marked with * in B). Representative histological (C and D) and immunohistochemical (E and F) images of retinal sections (RPE: retinal pigment epithelium; Ph: photoreceptor cells; INL: inner-nuclear layer; GCL: ganglion cell layer) show the embedded PCL scaffolds (marked with * and in E and F also autofluorescent in green) and surrounding tissue with some presumptive RPE cells (pigmented, shown with arrow in D) and photoreceptor cells (Recoverin positive, shown with arrows in F) infiltrating the scaffold. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)