Table 1.
Clinical biochemical information of the patients enrolled in this study.
| Parameters | NLF subjects | ALF subjects | P | ||
|---|---|---|---|---|---|
| Mean ± SD | Range | Mean ± SD | Range | ||
| Gender (male/female) | 5/5 | − | 8/5 | − | − |
| Age (years) | 7.3 ± 4.2 | 2–13 | 7.0 ± 5.0 | 0.5–14 | 0.895 |
| Weight (kg) | 32.4 ± 16.0 | 13–65 | 39.5 ± 25.4 | 9–85 | 0.449 |
| BMI | 18.3 ± 4.0 | 13.5–25.4 | 21.5 ± 4.7 | 15.0–28.4 | 0.102 |
| Daily dose (mg/kg) | 15.7 ± 5.1 | 7.7–23.8 | 14.0 ± 6.1 | 5.3–25.0 | 0.532 |
| VPA concentration (µg/mL) | 47.67 ± 26.85 | 11.33–82.32 | 57.52 ± 29.90 | 15.43–102.85 | 0.423 |
| Albumin (g/L) | 44.3 ± 3.4 | 38–49 | 45.4 ± 3.6 | 38–52 | 0.487 |
| ALT (U/L) | 11.3 ± 2.8 | 8–15 | 128.4 ± 57.1 | 88–251 | <0.001 |
| AST (U/L) | 21.4 ± 5.7 | 13–31 | 98.1 ± 68.8 | 39–298 | 0.002 |
| ALP (U/L) | 182.8 ± 35.1 | 145–229 | 244.5 ± 76.7 | 147–390 | 0.048 |
| GGT (U/L) | 12.1 ± 2.6 | 9–17 | 37.5 ± 25.0 | 13–90 | 0.010 |
| TBiL (µmol/L) | 7.32 ± 2.18 | 4.2–12.1 | 7.09 ± 3.11 | 3.0–13.4 | 0.841 |
| BUN (mmol/L) | 4.07 ± 0.86 | 2.9–5.4 | 4.27 ± 1.36 | 1.9–7.0 | 0.690 |
| Scr (µmol/L) | 32.5 ± 9.5 | 18.2–51.6 | 38.9 ± 12.4 | 15.6–56.2 | 0.194 |
Reference ranges: Albumin, 35–53 g/L; ALT, 0–40 U/L; AST, 5–34 U/L; ALP, 40–375 U/L; GGT, 9–64 U/L; BUN, 3–9.2 mmol/L; TBIL, 3.4–20.5 µmol/L; SCr, 45–84 µmol/L; VPA, 50–100 µg/ml.