Table 2. Association of Different Combinations of Body Mass Index and WC Status With All-Cause and Cause-Specific Mortality Among 156 624 Postmenopausal Womena.
| Modelb | HR (95% CI) | |||||
|---|---|---|---|---|---|---|
| Normal Weight | Overweight | Obesity | ||||
| Normal WC | High WC | Normal WC | High WC | Normal WC | High WC | |
| Participants, No. (%) | 52 735 (33.7) | 1390 (0.9) | 36 337 (23.2) | 18 572 (11.9) | 4957 (3.2) | 42 633 (27.2) |
| Any Cause Mortality | ||||||
| No. | 13 718 | 562 | 8722 | 6348 | 1093 | 13 395 |
| Model 1 | 1 [Reference] | 1.43 (1.31-1.55) | 0.92 (0.90-0.95) | 1.25 (1.21-1.28) | 0.93 (0.87-0.99) | 1.40 (1.36-1.43) |
| Model 2 | 1 [Reference] | 1.39 (1.28-1.51) | 0.91 (0.88-0.93) | 1.20 (1.17-1.24) | 0.90 (0.85-0.96) | 1.32 (1.29-1.35) |
| Model 3 | 1 [Reference] | 1.31 (1.20-1.42) | 0.91 (0.89-0.94) | 1.16 (1.13-1.20) | 0.93 (0.87-0.99) | 1.30 (1.27-1.34) |
| CVD Mortality | ||||||
| No. (%) | 3671 (26.8) | 149 (26.5) | 2534 (29.1) | 1954 (30.8) | 338 (30.9) | 4319 (32.2) |
| Model 1 | 1 [Reference] | 1.35 (1.15-1.60) | 1.00 (0.95-1.05) | 1.39 (1.32-1.47) | 1.08 (0.96-1.20) | 1.70 (1.63-1.78) |
| Model 2 | 1 [Reference] | 1.30 (1.10-1.53) | 0.97 (0.92-1.02) | 1.32 (1.25-1.39) | 1.02 (0.91-1.14) | 1.55 (1.48-1.63) |
| Model 3 | 1 [Reference] | 1.24 (1.05-1.46) | 0.97 (0.93-1.03) | 1.28 (1.21-1.35) | 1.04 (0.93-1.16) | 1.53 (1.46-1.61) |
| Cancer Mortality | ||||||
| No. (%) | 3708 (27.0) | 133 (23.7) | 2441 (28.0) | 1675 (26.4) | 303 (27.7) | 3568 (26.6) |
| Model 1 | 1 [Reference] | 1.33 (1.12-1.58) | 0.95 (0.90-1.01) | 1.25 (1.18-1.33) | 0.92 (0.82-1.03) | 1.29 (1.23-1.35) |
| Model 2 | 1 [Reference] | 1.30 (1.09-1.54) | 0.94 (0.90-0.99) | 1.22 (1.15-1.30) | 0.90 (0.80-1.02) | 1.24 (1.18-1.30) |
| Model 3 | 1 [Reference] | 1.20 (1.01-1.43) | 0.96 (0.92-1.02) | 1.19 (1.12-1.26) | 0.96 (0.85-1.08) | 1.26 (1.20-1.33) |
| Other Cause Mortality | ||||||
| No. (%) | 6339 (46.2) | 280 (48.9) | 3747 (43.0) | 2719 (42.8) | 452 (41.4) | 5508 (41.1) |
| Model 1 | 1 [Reference] | 1.54 (1.36-1.73) | 0.86 (0.83-0.90) | 1.16 (1.11-1.22) | 0.86 (0.78-0.94) | 1.30 (1.25-1.34) |
| Model 2 | 1 [Reference] | 1.50 (1.33-1.69) | 0.85 (0.82-0.89) | 1.13 (1.08-1.18) | 0.83 (0.76-0.91) | 1.24 (1.19-1.28) |
| Model 3 | 1 [Reference] | 1.42 (1.26-1.60) | 0.85 (0.82-0.88) | 1.09 (1.04-1.14) | 0.84 (0.76-0.93) | 1.20 (1.16-1.25) |
Abbreviations: CVD, cardiovascular disease; HR, hazard ratio; WC, waist circumference.
Body mass index calculated as weight in kilograms divided by height in meters squared and categorized as normal weight (18.5-24.9), overweight (25.0-29.9), and obesity (≥30.0). Waist circumference categorized as normal (≤88 cm) and high (>88 cm).
Model 1 adjusted for age at baseline and race/ethnicity. Model 2 additionally adjusted for education, income, component of Women’s Health Initiative (ie, randomized clinical trial or observational study), neighborhood socioeconomic status, unopposed estrogen usage status, and estrogen plus progesterone usage status. Model 3 additionally adjusted for smoking status, physical activity, total energy intake, and Alternative Healthy Eating Index 2010 score.