Table 5. Stratified Analyses for the Association of Baseline Body Mass Index and WC Status With Cancer Mortalitya,b.
| Characteristic | HR (95% CI) | P Value for Interaction | |||||
|---|---|---|---|---|---|---|---|
| Normal Weight | Overweight | Obesity | |||||
| Normal WC | High WC | Normal WC | High WC | Normal WC | High WC | ||
| Age, y | |||||||
| <65 | 1 [Reference] | 1.54 (1.02-2.33) | 0.94 (0.84-1.06) | 1.22 (1.06-1.40) | 0.95 (0.75-1.20) | 1.22 (1.09-1.36) | .31 |
| ≥65 | 1 [Reference] | 1.15 (0.95-1.39) | 0.97 (0.92-1.03) | 1.18 (1.11-1.26) | 0.96 (0.84-1.10) | 1.27 (1.20-1.35) | |
| Race | |||||||
| White | 1 [Reference] | 1.17 (0.97-1.40) | 0.98 (0.92-1.03) | 1.19 (1.12-1.27) | 0.90 (0.78-1.03) | 1.27 (1.21-1.34) | .27 |
| Nonwhite | 1 [Reference] | 1.54 (0.96-2.48) | 0.89 (0.77-1.03) | 1.15 (0.97-1.36) | 1.08 (0.86-1.36) | 1.19 (1.04-1.36) | |
| Smoking status | |||||||
| Never smoked | 1 [Reference] | 1.44 (1.09-1.92) | 0.98 (0.91-1.06) | 1.24 (1.13-1.37) | 0.99 (0.83-1.18) | 1.37 (1.27-1.49) | .17 |
| Ever smoked | 1 [Reference] | 1.10 (0.88-1.37) | 0.91 (0.85-0.98) | 1.13 (1.04-1.21) | 0.85 (0.72-1.01) | 1.09 (1.02-1.16) | |
| Physical activity, MET-h/wk | |||||||
| <10 | 1 [Reference] | 1.29 (1.03-1.61) | 0.94 (0.87-1.01) | 1.14 (1.05-1.23) | 0.93 (0.79-1.09) | 1.21 (1.14-1.30) | .046 |
| ≥10 | 1 [Reference] | 0.98 (0.72-1.32) | 0.97 (0.90-1.05) | 1.23 (1.13-1.35) | 0.98 (0.82-1.18) | 1.32 (1.22-1.43) | |
| Unopposed estrogen use | |||||||
| Never used | 1 [Reference] | 1.16 (0.93-1.45) | 0.95 (0.89-1.01) | 1.18 (1.09-1.27) | 0.97 (0.84-1.12) | 1.25 (1.17-1.32) | .90 |
| Ever used | 1 [Reference] | 1.29 (0.98-1.70) | 1.00 (0.91-1.08) | 1.22 (1.11-1.34) | 0.94 (0.76-1.15) | 1.32 (1.21-1.43) | |
| Estrogen plus progesterone use | |||||||
| Never used | 1 [Reference] | 1.26 (1.04-1.53) | 0.96 (0.90-1.02) | 1.21 (1.14-1.30) | 0.97 (0.85-1.11) | 1.26 (1.19-1.33) | .35 |
| Ever used | 1 [Reference] | 0.98 (0.64-1.49) | 0.98 (0.89-1.09) | 1.10 (0.96-1.25) | 0.92 (0.71-1.19) | 1.30 (1.17-1.44) | |
| AHEI-2010 score | |||||||
| ≤50 | 1 [Reference] | 1.11 (0.87-1.42) | 0.90 (0.83-0.97) | 1.13 (1.05-1.23) | 0.91 (0.77-1.07) | 1.19 (1.11-1.27) | .02 |
| >50 | 1 [Reference] | 1.24 (0.96-1.60) | 1.04 (0.96-1.11) | 1.26 (1.16-1.38) | 1.04 (0.87-1.23) | 1.37 (1.27-1.48) | |
| NSES | |||||||
| ≤75 | 1 [Reference] | 1.54 (1.18-2.01) | 1.01 (0.93-1.11) | 1.11 (0.99-1.23) | 0.97 (0.81-1.17) | 1.27 (1.17-1.38) | .02 |
| >75 | 1 [Reference] | 1.02 (0.80-1.32) | 0.94 (0.88-1.01) | 1.23 (1.14-1.33) | 0.91 (0.77-1.08) | 1.25 (1.17-1.34) | |
Abbreviations: AHEI, Alternative Healthy Eating Index; HR, hazard ratio; MET-h, metabolic equivalent of task hours; NSES, neighborhood socioeconomic status; WC, waist circumference.
Based on model 3, ie, adjusted for age at baseline, race/ethnicity, education, income, NSES, component of Women’s Health Initiative (ie, randomized clinical trial or observational study), unopposed estrogen usage status, estrogen plus progesterone usage status, smoking status, physical activity, total energy intake, and AHEI-2010 score.
Body mass index calculated as weight in kilograms divided by height in meters squared and categorized as normal weight (18.5-24.9), overweight (25.0-29.9), and obesity (≥30). Waist circumference categorized as normal (≤88 cm) and high (>88 cm).