Table 2. Multivariable Analysis for Overall Survival and Progression-Free Survival in Pooled ICI-Treated and TT-Treated Patients.
| Variable | Hazard Ratio (95% CI) | |||
|---|---|---|---|---|
| ICI Group (n = 1368) | TT Group (n = 1110) | |||
| Progression-Free Survival | Overall Survival | Progression-Free Survival | Overall Survival | |
| Age, y | ||||
| <65 | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| ≥65 | 0.96 (0.82-1.11) | 0.95 (0.80-1.12) | 0.97 (0.80-1.18) | 1.30 (0.97-1.72) |
| P value | .56 | .53 | .78 | .08 |
| Sex | ||||
| Male | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| Female | 1.13 (0.97-1.33) | 0.98 (0.82-1.17) | 1.01 (0.82-1.24) | 1.01 (0.75-1.37) |
| P value | .12 | .83 | .96 | .95 |
| Histologic characteristics | ||||
| Nonsquamous | 1 [Reference] | 1 [Reference] | NA | NA |
| Squamous | 1.21 (1.01-1.46) | 1.24 (1.01-1.51) | NA | NA |
| P value | .04 | .04 | NA | NA |
| Smoking | ||||
| Never smoker | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| Anytime smoker | 0.57 (0.44-0.74) | 1.00 (0.74-1.36) | 1.25 (1.02-1.54) | 1.36 (1.01-1.83) |
| P value | <.001 | .98 | .03 | .046 |
| ECOG PS | ||||
| ECOG PS of 0 | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| ECOG PS of ≥1 | 1.14 (0.97-1.35) | 1.61 (1.33-1.95) | 1.12 (0.93-1.35) | 1.47 (1.11-1.97) |
| P value | .11 | <.001 | .24 | .008 |
| LDH | ||||
| ≤ULN | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| >ULN | 1.19 (1.02-1.40) | 1.44 (1.21-1.71) | 1.46 (1.20-1.77) | 1.70 (1.27-2.27) |
| P value | .03 | <.001 | <.001 | <.001 |
| dNLR | ||||
| ≤3 | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| >3 | 1.26 (1.06-1.49) | 1.64 (1.37-1.96) | 1.54 (1.26-1.88) | 1.87 (1.41-2.48) |
| P value | .008 | <.001 | <.001 | <.001 |
| Albumin | ||||
| ≥3.5 g/dL | 1 [Reference] | 1 [Reference] | 1 [Reference] | 1 [Reference] |
| <3.5 g/dL | 1.22 (1.00-1.48) | 1.57 (1.29-1.91) | 1.04 (0.84-1.28) | 1.66 (1.24-2.22) |
| P value | .045 | <.001 | .74 | <.001 |
| PD-L1 | ||||
| ≥1% | 1 [Reference] | 1 [Reference] | NA | NA |
| <1% | 1.72 (1.46-2.03) | 1.20 (1.00-1.45) | NA | NA |
| P value | <.001 | .06 | NA | NA |
Abbreviations: dNLR, derived neutrophil to lymphocyte ratio (leukocytes minus neutrophils); ECOG PS, Eastern Cooperative Oncology Group Performance Score; ICI, immune checkpoint inhibitor; LDH, lactate dehydrogenase; NA, not applicable; PD-L1, programmed death ligand 1; TT, targeted therapy; ULN, upper limit of normal.
SI conversion factor: To convert albumin to grams per liter, multiply by 10.0.