. 2019 Jul 24;76(11):1198–1205. doi: 10.1001/jamapsychiatry.2019.1694

Table 5. Associations of Markers of Methylation Status and Transsulfuration Status With Brain Volumes at Baseline and Change in Brain Tissue Volumes During 6 Years .

Variable	Total Brain Tissue Volune		Gray Matter Volume		White Matter Volume		White Matter Hyperintensity Volumes
Variable	β (SE) for the Multiadjusted Model^a	P Value	β (SE) for the Multiadjusted Model^a	P Value	β (SE) for the Multiadjusted Model^a	P Value	β (SE) for the Multiadjusted Model^a	P Value
Methionine to Homocysteine Ratio
Cross-sectional^b	0.477 (0.167)	.004	0.187 (0.125)	.14	0.340 (0.164)	.04	−0.00002 (0.0001)	.74
Longitudinal analysis	0.038 (0.014)	.007	0.034 (0.012)	.003	0.007 (0.012)	.55	−0.000001 (0.000001)	.32
Cystathionine to Homocysteine Ratio
Cross-sectional^b	0.202 (0.137)	.13	−0.070 (0.103)	.497	0.269 (0.137)	.051	0.00007 (0.00005)	.16
Longitudinal analysis	−0.008 (0.012)	.51	0.003 (0.010)	.78	−0.004 (0.010)	.65	−0.000001 (0.000005)	.65

^{^a}

Adjusted for age, sex, educational level, creatinine level, systolic blood pressure, use of vitamins, albumin level, smoking status, history of cardiovascular conditions, and APOE-ε4 status.

^{^b}

For cross-sectional analysis, the sample size was 470; for longitudinal analysis, the sample size was 281 for those with available follow-up magnetic resonance imaging.