Figure 1.

BAY1143572 is an effective cytotoxic agent in vitro and in vivo.

Esophageal adenocarcinoma cells were treated with BAY1143572 at the indicated doses for 48 h and then assessed for cell proliferation by MTS assay (A) and for apoptosis by flow cytometry (B). (C) Xenograft-bearing mice were treated with vehicle (DMSO) or with 12.5 or 15 mg/kg BAY1143572 by intraperitoneal injection daily for 10 days. Data are the mean percentages of tumor growth ± SE. ^*p < 0.05 compared with untreated controls. (D) Body weight chart of the xenograft-bearing mice treated with vehicle or with 12.5 or 15 mg/kg BAY1143572.