Table 2.
Laboratory findings (the past 30 years; 1985–2015)
| A. measurements of respiratory function tests | ||||
|
Total (n = 316) Mean (±SD) |
Age at diagnosis < 18 (n = 92) Mean (±SD) |
Age at diagnosis ≥18 (n = 148) Mean (±SD) |
P valuea | |
| VC (% predicted) | n = 63 | n = 10 | n = 37 | |
| 71.3 (±22.5) | 68.3 (±30.7) | 71.2 (±21.4) | 0.650 | |
| FEV1/FVC ratio (%) | n = 77 | n = 10 | n = 42 | |
| 63.3 (±15.0) | 75.7 (±12.7) | 60.3 (±16.1) | 0.005 | |
| FEV1 (% predicted) | n = 9 | n = 3 | n = 6 | |
| 48.1 (±27.4) | 35.4 (±29.7) | 54.4 (±26.5) | 0.262 | |
| RV/TLC ratio (%) | n = 26 | n = 1 | n = 8 | |
| 44.2 (±15.1) | 24.3 | 45.5 (±17.3) | 0.444 | |
| B. frequencies of pathogens detected in bacterial cultures and frequencies of other tests | ||||
|
Total (n = 316) n (%) |
Age at diagnosis < 18 (n = 92) n (%) |
Age at diagnosis ≥18 (n = 148) n (%) |
P value (chi-square test) | |
| Bacterial sputum culture | n = 75 | n = 10 | n = 41 | |
| Pseudomonas aeruginosa | 32 (42.7) | 5 (50.0) | 13 (31.7) | 0.278 |
| Haemophilus influenzae | 27 (36.0) | 2 (20.0) | 15 (10.1) | 0.319 |
| Klebsiella pneumoniae | 7 (9.3) | 0 | 4 (9.8) | 0.304 |
| Streptococcus pneumoniae | 6 (8.0) | 2 (20.0) | 3 (7.3) | 0.227 |
| Staphylococcus aureus | 2 (2.7) | 0 | 2 (4.9) | 0.476 |
| Aspergillus fumigatus | 2 (2.7) | 0 | 2 (4.9) | 0.476 |
| Normal flora | 12 (16.0) | 2 (20.0) | 8 (19.5) | 0.972 |
| Sputum acid-fast bacteria culture | n = 17 | n = 2 | n = 14 | |
| Mycobacterium avium complex | 5 (29.4) | 0 | 4 (28.6) | 0.383 |
| Mycobacterium tuberculosis | 1 (5.9) | 0 | 1 (7.1) | 0.696 |
| Negative | 11 (64.7) | 2 (100) | 9 (64.3) | 0.308 |
| Saccharin test | n = 33 | n = 8 | n = 25 | 0.073 |
| Nasal NO test | n = 4 | n = 2 | n = 2 | 0.628 |
VC (vital capacity), FEV1 (forced expiratory volume in one second), FVC (forced vital capacity), RV (residual volume), TLC (total lung capacity), Nasal NO (nasal nitric oxide)
aExact Wilcoxon rank sum test