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. 2019 Jul 25;7:119. doi: 10.1186/s40478-019-0774-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Morphological similarity of the tumor cells between those in the orthotopic xenograft (a, b, c) and those from the patient (d, e, f). The orthotopic xenografts share strikingly similar characteristics to those of the autopsy specimen, including the mode of tumor infiltration (a, d) and the light microscopic (b, e) and ultrastructural (c, f) morphology of the tumor cells. Scale bars a, d: 200 μm; b, e: 50 μm; c, F: 2 μm