Table 4.
Changes of the inflammatory and structural parameters between baseline and week 24
| Characteristic | Baseline | Week 24 | p value |
|---|---|---|---|
| MRI | |||
| PSAMRIS synovitis (median, IQR) (mean ± SD)† | 1 (0, 2); 2.17 ± 4.61 | 1 (0, 2); 1.06 ± 1.96 | 0.008** |
| PSAMRIS osteitis (median, IQR) (mean ± SD)† | 0 (0, 0); 0.44 ± 1.89 | 0 (0, 0); 0.33 ± 1.41 | 0.317 |
| PSAMRIS periarticular (median, IQR) (mean ± SD)† | 0 (0, 0); 0.28 ± 0.67 | 0 (0, 0); 0 ± 0 | 0.102 |
| PSAMRIS tenossynovitis (median, IQR) (mean ± SD)† | 0 (0, 1); 0.61 ± 1.15 | 0 (0, 0); 0.33 ± 0.84 | 0.096 |
| PSAMRIS erosions (median, IQR) | 2 (0, 4) | 2 (0, 4) | 1.000 |
| PSAMRIS proliferation (median, IQR) (mean ± SD)† | 0 (0, 1); 0.44 ± 0.71 | 0 (0, 1); 0.44 ± 0.86 | 1.000 |
| Total PSAMRIS (median, IQR) | 5 (1, 8) | 3 (0, 6) | 0.005** |
| HR-pQCT | |||
| Erosion number (median, IQR) | 1 (0, 1.75) | 1 (0, 1.75) | 0.317 |
| Proliferation grade (median, IQR) (mean ± SD)† | 0 (0, 1); 0.55 ± 0.76 | 0 (0, 2); 0.68 ± 0.89 | 0.180 |
| Dtot, HA/cm3 (median, IQR) | 303.1 (264.8, 320.8) | 308.9 (265.8, 324.9) | 0.020* |
| Dtrab, HA/cm3 (median, IQR) | 165.2 (133.5, 205.7) | 165.7 (136.9, 206.9) | 0.048* |
| Dcomp, HA/cm3 (median, IQR) | 840.5 (778.8, 848.3) | 831.1 (796.5, 854.8) | 0.184 |
| Bone stiffness, kN/mm (median, IQR) | 48.38 (38.58, 60.31) | 49.40 (38.14, 59.82) | 0.501 |
| Failure load, N (median, IQR) | 2312.2 (1862.6, 2817.0) | 2390.0 (1798.6, 2847.2) | 0.352 |
Data are based on 18 psoriasis patients with complete baseline and 24-week data
PSAMRIS psoriatic arthritis magnetic resonance imaging scoring system, MRI magnetic resonance imaging, HR-pQCT high-resolution peripheral quantitative computed tomography, IQR interquartile range, Dtot average bone density, HA hydroxyapatite, Dtrab trabecular bone density, Dcomp cortical bone density, N Newton
†Additionally reported as mean and standard deviation (mean ± SD) because median was equal to zero
Wilcoxon signed-rank test. *p ≤ 0.05, **p ≤ 0.01