Table 2.
Toxicity classification calculations for each flavouring compound using the maximum concentrations reported by Vardavas et al.
| Substance | Hazard category | Reported max concentration (% w/w)* |
Calculated ATEmix | ATEmix limit or min concentration for toxicity classification | % difference** |
|---|---|---|---|---|---|
| Menthol | Η315 Category 2 | 0.4991 | 10 | − 95.0% | |
| Η319 Category 2 | 0.4991 | 10 | − 95.0% | ||
| Ethyl maltol | Η302 Category 4 | 7.096 | 7046 | ≤ 2000 | − 71.6% |
| Linalool | Η315 Category 2 | 0.263 | 10 | − 97.4% | |
| Η317 Category 1 | 0.263 | 1 | − 73.7% | ||
| Η319 Category 2 | 0.263 | 10 | − 97.4% | ||
| Methyl cyclopentenolone | Η302 Category 4 | 2.5067 | 19,946 | ≤ 2000 | − 90.0% |
| Η319 Category 2 | 2.5067 | 10 | − 74.9% | ||
| Η334 Category 1 | 2.5067 | 1 | 150.7% | ||
| Η335 Category 3 | 2.5067 | 20 | − 87.5% | ||
| β-Damascone | Η317 Category 1 | 0.0742 | 1 | − 92.6% | |
| Η411 Category 2 | 0.0742 | 25 | − 99.7% | ||
| Ethyl vanillin | Η302 Category 4 | 0.9135 | 54,734 | ≤ 2000 | − 96.3% |
| Η315 Category 2 | 0.9135 | 10 | − 90.9% | ||
| Η319 Category 2 | 0.9135 | 10 | − 90.9% | ||
| Η335 Category 3 | 0.9135 | 20 | − 95.4% | ||
| Η412 Category 3 | 0.9135 | 25 | − 96.3% | ||
| β-Ionone | Η400 Category 1 | 0.0076 | 25 | > − 99.9% | |
| Η411 Category 2 | 0.0076 | 25 | > − 99.9% | ||
| Acetyl pyrazine | Η315 Category 2 | 0.1067 | 10 | − 98.9% | |
| Η319 Category 2 | 0.1067 | 10 | − 98.9% | ||
| Η335 Category 3 | 0.1067 | 20 | − 99.5% | ||
| α-Ionone | Η334 Category 1 | 0.012 | 1 | − 98.8% | |
| Η412 Category 3 | 0.012 | 25 | > − 99.9% | ||
| 2,5 Dimethylpyrazine | Η302 Category 4 | 0.0197 | 2,538,071 | ≤ 2000 | − 99.9% |
| α-Damascone | Η302 Category 4 | 0.0078 | 6,410,256 | ≤ 2000 | > − 99.9% |
| Η317 Category 1 | 0.0078 | 1 | − 99.2% | ||
| Η411 Category 2 | 0.0078 | 25 | > − 99.9% | ||
| 3,4 Dimethoxy-benzaldehyde | Η302 Category 4 | 0.0359 | 1,392,757 | ≤ 2000 | − 99.9% |
| Limonene | Η304 Category 1 | 0.0001 | 10 | > − 99.9% | |
| Η315 Category 2 | 0.0001 | 10 | > − 99.9% | ||
| Η317 Category 1 | 0.0001 | 1 | > − 99.9% | ||
| Η400 Category 1 | 0.0001 | 25 | > − 99.9% | ||
| Η410 Category 1 | 0.0001 | 25 | > − 99.9% |
*Maximum concentrations reported by Vardavas et al
**Percent difference between the maximum concentration reported by Vardavas et al. and the concentration needed to be classified as toxic
Italics represents the compound and hazard exceeding the limits for toxicity classification