Fig. 2.

Overview of consecutive cases reviewed by GM-MDT during period April 2014–February 2015. a Flow chart describing case allocation for NGS and outcome of ES. b Investigation prior to GM-MDT referral. c Summary of referrals by class of disorder based on working diagnosis (presenting complaint) and age. d Summary of cases by referring department and approval. e Reasons for failure to approve cases (more than one may apply to a given case). Issues relating to the phenotype included complexity, variability, issues with affected status of family members and need for formal clinical genetics review