Table 1.
Characteristics of the studies included in this meta-analysis
| Author/year of publication | Country | Gender | Mean age (Y) | Intervention | Follow-up (d) | Study design | Outcomes assessed | |
|---|---|---|---|---|---|---|---|---|
| PRF | Control | |||||||
| Gürbüzer/2010 [28] | Turkey | 7 males and 7 females | 24.92 ± 4.69Y | 14 | 14 | 28d | RCT, split-mouth | Osteoblastic activity |
| Eshghpour/2014 [29] | Iran | 33 males and 45 females | 25.09 ± 4.25Y | 78 | 78 | 2 and 7d | RCT, split-mouth | Alveolar osteitis |
| Baslarli/2015 [30] | Turkey | 7 males and 13 females | 23.9Y | 20 | 20 | 30 and 90d | RCT, split-mouth | Alveolar osteitis, osteoblastic activity |
| Kumar/2015 [31] | India | NA | PRF:25.25 ± 4.2Y Control:27 ± 5.27Y | 16 | 15 | 90d | RCT | Trismus |
| Ozgul/2015[32] | Turkey | 23 males and 33 females | NA | 56 | 56 | 1,3, and 7d | RCT, split-mouth | Pain, swelling |
| Uyanık/2015 [33] | Cyprus | 4 males, 6 females | 22.65Y | 10 | 10 | 1,2,3, and 7d | RCT, split-mouth | Pain, swelling, trismus |
| Bilginaylar/2016 [34] | Cyprus | 22 males and 37 females | PRF:21.75Y Control:22.5Y | 40 | 40 | 1,2,3, and 7d | RCT | Pain, swelling, trismus |
| Dutta/2016 [19] | India | 27 males and 13 females | 27 ± 5Y | 10 | 10 | 3,7, and 14d | RCT | Pain, swelling, soft tissue healing |
| Al-Hamed/2017 [16] | Egypt | 13 males and 34 females | 25.24 ± 7.04Y | 25 | 25 | 2,3,4,5,6, and 7d | RCT | Pain, alveolar osteitis, soft tissue healing |
| Gülşen/2017 [21] | Turkey | 21 males and 9 females | 20.03Y | 30 | 30 | 1,2,3, and 7d | RCT, split-mouth | Pain |
Y years, d days, RCT randomized controlled trial, NA Not available