Table 2.
Univariate and age- and FIT-adjusted predictors of ACN in the derivation (Phase I) cohort: Crude and adjusted ORs, and C-Statistic and Brier score of the adjusted model
| VARIABLE | Control group (Non-AA, non-CRC) |
AA+CRC | OR (Crude) [95%CI] |
OR (Adjusted) [95%CI] |
C-Statistic/ Brier score adjusted model |
|---|---|---|---|---|---|
| N = 696 | N = 171 | ||||
| Gender | |||||
| Man | 311 (44.7%) | 103 (60.2%) | Ref. | Ref. | |
| Woman | 385 (55.3%) | 68 (39.8%) | 0.53 [0.38;0.75] | 0.81 [0.53;1.21] | 0.841 / 0.1158 |
| Body Mass Index (Kg/m2) | |||||
| ≤ 25 | 246 (35.3%) | 47 (27.5%) | Ref. | Ref. | |
| > 25 | 450 (64.7%) | 124 (72.5%) | 1.44 [1.01;2.10] | 1.19 [0.77;1.85] | 0.841 / 0.1161 |
| Colonoscopy (5 years before) | |||||
| No | 555 (79.7%) | 153 (89.5%) | Ref. | Ref. | |
| Yes | 141 (20.3%) | 18 (10.5%) | 0.47 [0.27;0.77] | 0.35 [0.21;0.63] | 0.862 / 0.1031 |
| Smoking (History) | |||||
| No | 359 (51.6%) | 77 (45.0%) | Ref. | Ref. | |
| Yes (Ex/Current) | 337 (48.4%) | 94 (55.0%) | 1.30 [0.93;1.82] | 1.51 [1.02;2.29] | 0.859 / 0.1050 |
| Smoking (Years): | |||||
| No | 359 (51.6%) | 77 (45.0%) | Ref. | Ref. | |
| ≤ 42 | 191 (27.4%) | 25 (14.6%) | 0.61 [0.37;0.98] | 1.17 [0.6;2.33] | |
| > 42 | 146 (21.0%) | 69 (40.4%) | 2.20 [1.51;3.21] | 1.65 [0.99;2.61] | 0.849 / 0.1086 |
| Drugs (NSAIDs or antiplatelet or anticoagulants) | |||||
| No | 415 (59.6%) | 98 (57.3%) | Ref. | Ref. | |
| Yes | 281 (40.4%) | 73 (42.7%) | 1.10 [0.78;1.54] | 0.79 [0.52;1.21] | 0.841 / 0.1153 |
| Anticoagulants | |||||
| No | 673 (96.7%) | 156 (91.2%) | Ref. | Ref. | |
| Yes | 23 (3.30%) | 15 (8.77%) | 2.82 [1.40;5.50] | 1.67 [0.75;3.80] | 0.842 / 0.1159 |
| NSAIDs | |||||
| No | 525 (75.4%) | 136 (79.5%) | Ref. | Ref. | |
| Yes | 171 (24.6%) | 35 (20.5%) | 0.79 [0.52;1.18] | 0.79 [0.49;1.29] | 0.846 / 0.1156 |
| Abdominal pain | |||||
| No | 299 (43.0%) | 97 (56.7%) | Ref. | Ref. | |
| Yes | 397 (57.0%) | 74 (43.3%) | 0.58 [0.41;0.81] | 0.77 [0.52;1.16] | 0.840 / 0.116 |
| Iron deficiency | |||||
| No | 237 (34.1%) | 56 (32.7%) | Ref. | Ref. | |
| Yes | 174 (25.0%) | 55 (32.2%) | 1.34 [0.88;2.04] | 0.92 [0.55;1.92] | |
| Unknown | 285 (40.9%) | 60 (35.1%) | 0.89 [0.59;1.34] | 0.86 [0.54;1.37] | 0.840 / 0.116 |
| Iron deficiency anaemia | |||||
| No | 371 (53.3%) | 77 (45.0%) | Ref. | Ref. | |
| Yes | 166 (23.9%) | 54 (31.6%) | 1.57 [1.05;2.32] | 1.13 [0.69;1.84] | |
| Unknown | 159 (22.8%) | 40 (23.4%) | 1.21 [0.79;1.85] | 1.14 [0.69;1.91] | 0.840 / 0.116 |
| Type change bowel habit | |||||
| No | 261 (37.5%) | 78 (45.6%) | Ref. | Ref. | |
| Diarrhoea | 226 (32.5%) | 59 (34.5%) | 0.87 [0.59;1.28] | 1.08 [0.68;1.71] | |
| Constipation | 179 (25.7%) | 31 (18.1%) | 0.58 [0.36;0.91] | 0.71 [0.42;1.22] | |
| Unknown | 30 (4.31%) | 3 (1.75%) | 0.35 [0.08;1.02] | 0.78 [0.23;2.74] | 0.840 / 0.1153 |
| Abdominal pain duration | |||||
| No | 299 (43.0%) | 97 (56.7%) | Ref. | Ref. | |
| Yes, 1–12 Days | 123 (17.7%) | 26 (15.2%) | 0.65 [0.40;1.05] | 0.65 [0.37;1.15] | |
| Yes, > 12 Days | 274 (39.4%) | 48 (28.1%) | 0.54 [0.37;0.79] | 0.86 [0.54;1.37] | 0.850 / 0.1157 |
| Rectal bleeding pattern | |||||
| No | 342 (49.1%) | 84 (49.1%) | Ref. | Ref. | |
| Yes, without specific pattern | 219 (31.5%) | 43 (25.1%) | 0.80 [0.53;1.20] | 0.59 [0.36;1.07] | |
| Yes, with specific pattern | 135 (19.4%) | 44 (25.7%) | 1.44 [0.97;2.12] | 1.33 [0.87;2.01] | 0.849 / 0.1151 |
| Rectal bleeding duration (days) | |||||
| No rectal bleeding | 342 (49.1%) | 84 (49.1%) | Ref. | Ref. | |
| ≤ 30 | 328 (47.1%) | 74 (43.3%) | 0.92 [0.65;1.30] | 0.63 [0.41;1.05] | |
| > 30 | 26 (3.74%) | 13 (7.60%) | 2.04 [0.97;4.10] | 0.86 [0.37;1.98] | 0.846 / 0.1150 |
| Haemoglobin (g/dL) | |||||
| ≤ 11 | 105 (15.1%) | 43 (25.1%) | Ref. | Ref. | |
| > 11 | 481 (69.1%) | 112 (65.5%) | 0.57 [0.38;0.86] | 1.02 [0.61;1.71] | |
| Unknown | 110 (15.8%) | 16 (9.36%) | 0.36 [0.18;0.67] | 0.62 [0.31;1.31] | 0.847 / 0.1127 |
| Ferritin (ng/mL) | |||||
| ≤ 40 | 176 (25.3%) | 56 (32.7%) | Ref. | Ref. | |
| > 40 | 225 (32.3%) | 53 (31.0%) | 0.74 [0.48;1.13] | 0.82 [0.51;1.34] | |
| Unknown | 295 (42.4%) | 62 (36.3%) | 0.66 [0.44;0.99] | 0.85 [0.52;1.39] | 0.849 / 0.1106 |
| CEA (ng/mL) | |||||
| ≤ 12 | 610 (87.6%) | 135 (78.9%) | Ref. | Ref. | |
| > 12 | 5 (0.72%) | 11 (6.43%) | 9.73 [3.43;32.1] | 2.91 [0.88;9.36] | |
| Unknown | 81 (11.6%) | 25 (14.6%) | 1.40 [0.85;2.25] | 1.27 [0.71;2.27] | 0.849 / 0.1101 |