Table 5.
Probability of an individual classified based on its risk score (after applying the score derived from Phase 1 to the validation cohort, Phase 2). The cut-off points were selected using the ‘AddFor’ algorithm (see methods)
| Score | Prob (Control group)* | Prob (AA) | Prob (CRC) | Prob (Control group)* (95% CI) |
Prob (AA+CRC) (95% CI) |
|---|---|---|---|---|---|
| > 20 | 0.34 | 0.34 | 0.32 | 0.34 (0.28; 0.39) | 0.66 (0.51; 0.76) |
| 10–20 | 0.76 | 0.16 | 0.07 | 0.76 (0.65; 0.86) | 0.24 (0.14; 0.31) |
| ≤10 | 0.90 | 0.09 | 0.01 | 0.90 (0.84; 0.97) | 0.10 (0.01; 0.16) |
*Control group: Non-AA, non-CCR