Table 3.
Crude and adjusted analysis of the association between age and adjuvant chemotherapy in stage III colon cancer
| Adjuvant chemotherapy for stage III colon cancer | ||||
|---|---|---|---|---|
| 3A. Univariate analysis | 3B. Multivariate analysis | |||
| n (%) | P value | Odds Ratio (95% CI) | P value | |
| Age, years | ||||
| < 65 | 226 (91.9) | < 0.0005b | 1 | |
| 65–80 | 239 (76.8) | 0.3 (0.1–0.6) | 0.001 | |
| > 80 | 26 (26.8) | 0.04 (0.02–0.09) | < 0.0005 | |
| Sex | ||||
| Male | 309 (74.3) | 0.57a | ||
| Female | 182 (76.5) | |||
| Deprivation index | ||||
| Quartile 1 | 106 (79.7) | 0.29b | ||
| Quartile 2 | 142 (72.4) | |||
| Quartile 3 | 121 (75.2) | |||
| Quartile 4 | 97 (72.4) | |||
| Level of education | ||||
| No formal | 47 (66.2) | < 0.0005b | 1 | |
| Primary | 253 (75.5) | 1.2 (0.7–2.2) | 0.46 | |
| Secondary | 53 (85.5) | 1.6 (0.4–5.5) | 0.46 | |
| University | 59 (89.4) | 1.6 (0.5–5.7) | 0.45 | |
| Living arrangement | ||||
| Living alone | 56 (70.9) | 0.2a | ||
| Living with others | 345 (77.9) | |||
| Family history of cancer | ||||
| No | 257 (71.2) | < 0.0005a | 1 | |
| Yes | 194 (87.0) | 1.9 (0.7–5.0) | 0.21 | |
| Screening | ||||
| No | 368 (72.2) | 0.001a | 1 | |
| Yes | 97 (86.6) | 1.0 (0.4–2.2) | 0.99 | |
| Smoking habits | ||||
| Never smoker | 241 (76.3) | 0.516a | ||
| Current smoker | 61 (79.2) | |||
| Ex-smoker | 187 (73.3) | |||
| Alcohol | ||||
| No | 392 (74.1) | 0.42a | ||
| Yes | 63 (75.9) | |||
| Charlson index | ||||
| 0 | 296 (82.0) | < 0.0005b | 1 | |
| 1 | 114 (73.5) | 0.8 (0.5–1.4) | 0.43 | |
| ≥ 2 | 81 (58.7) | 0.6 (0.3–1.2) | 0.17 | |
| ASA class | ||||
| I-II | 309 (85.4) | < 0.0005b | 1 | |
| III | 155 (64.9) | 0.6 (0.3–1.1) | 0.10 | |
| IV | 10 (31.3) | 0.1 (0.03–0.3) | < 0.0005 | |
| Site | ||||
| Rectosigmoid junction | 78 (81.3) | 0.19a | 1 | |
| Distal colon | 219 (75.8) | 0.5 (0.2–1.4) | 0.18 | |
| Proximal colon | 194 (72.1) | 0.5 (0.2–1.6) | 0.25 | |
| Degree of differentiation | ||||
| Low grade | 354 (75.3) | 0.12a | 1 | |
| High grade | 85 (82.5) | 1.2 (0.4–3.4) | 0.70 | |
| Histological classification | ||||
| Adenocarcinoma | 439 (75.7) | 0.29a | ||
| Mucinous Adenocarcinoma | 38 (73.1) | |||
| Signet-ring cell carcinoma | 8 (100.0) | |||
| Other carcinomas | 3 (100.0) | |||
| Cancer committee | ||||
| No | 180 (72.6) | 0.30a | ||
| Yes | 282 (76.4) | |||
| Surgeon’s profile | ||||
| General | 134 (69.4) | 0.07a | 1 | |
| Coloproctologist | 323 (76.5) | 1.3 (0.6–3.1) | 0.50 | |
| Curative resection | ||||
| R0 | 428 (76.0) | 0.62a | ||
| R1/R2 | 40 (72.7) | |||
aPearson Chi-square test
bChi-square test for trends