Table 2.

MR Egger and weighted median approaches to assess the association between genetically predicted PCOS and ovarian cancer risk, overall and by histotype

	MR Egger		Weighted median
	OR (95% CI)	P-value	OR (95% CI)	P-value
Borderline	0.96 (0.50–1.88)	0.91	1.05 (0.87–1.27)	0.63
Serous	0.89 (0.39–2.03)	0.79	1.07 (0.85–1.37)	0.56
Mucinous	1.28 (0.45–3.64)	0.65	1.19 (0.88–1.60)	0.26
Invasive	1.02 (0.71–1.48)	0.91	0.92 (0.84–1.01)	0.09
Low-grade serous	1.89 (0.52–6.86)	0.33	1.28 (0.90–1.83)	0.17
High-grade serous	1.23 (0.80–1.89)	0.36	0.91 (0.81–1.01)	0.09
Mucinous	0.81 (0.32–2.10)	0.67	1.20 (0.91–1.58)	0.20
Endometrioid	0.43 (0.20–0.93)	0.03	0.70 (0.56–0.87)	0.001
Clear cell	1.15 (0.44–2.96)	0.78	0.85 (0.64–1.12)	0.24