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. 2019 May 29;48(3):807–816. doi: 10.1093/ije/dyz107

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© The Author(s) 2019; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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Multivariable inverse-variance weighted Mendelian randomization estimates between sex hormone binding globulin (SHBG) concentrations and risk of breast cancer, adjusting for the genetic effects of body mass index (BMI). Main analysis: the odds ratios represent increase/decrease of risk per 25nmol/L increase in SHBG levels (N = 12 SNPs). Sensitivity analysis 1: we used 11 SNPs after excluding rs780093 due to potential pleiotropy with several other traits.^41–44 Sensitivity analysis 2: we used nine SNPs after excluding rs1641537, rs1625895 and rs3779195 derived from conditional analyses in the GWAS of SHBG.²⁰ Sensitivity analysis 3: we used as instruments only the three SNPs (i.e. rs12150660, rs7910927, rs780093), which were significant in the GWAS analysis for SHBG only in women.²⁰ Sensitivity analysis 4: we used female-specific estimates for the SNP-SHBG associations (for three SNPs i.e. rs1641537, rs1625895 and rs3779195, estimates were only reported in males and females together).²⁰.