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. 2019 May 7;48(3):849–860. doi: 10.1093/ije/dyz071

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© The Author(s) 2019. Published by Oxford University Press on behalf of the International Epidemiological Association.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Study design.

N, number of observations; HES, Hospital Episode Statistics; SNP, single-nucleotide polymorphism; MR, Mendelian randomization; G-X, genetic association of instrument (SNP) with exposure; G-Y, genetic association of instrument (SNP) with outcome; IGAP, International Genomics of Alzheimer’s Project.