Figure 2.

Multilevel random intercept and slope model findings. (A‐H) Graphs illustating each liver response trajectory over time (dashed lines) with corresponding average trajectory predicted from the multilevel model (solid lines) for LC and non‐LC livers. (A) Log‐transformed lactate levels (mmol/L): a significant difference in trend over time (P < 0.001) was observed, with LC livers being lower in comparison to non‐LC livers. (B) The pH: on average, LC livers appear to have a gentler increasing trend compared with non‐LC livers (P = 0.10), after adjustment for bicarbonate, carbon dioxide, and excess base. (C) Hepatic arterial pressure (mm Hg): the trends were different with a much steeper increasing trend in the non‐LC livers (P = 0.08), after adjusting for pressure and resistance. (D) Hepatic artery flow (mL/minute): there appears to be a difference in trends between LC and non‐LC groups (P = 0.13) after adjusting for hepatic arterial pressure, hepatic arterial resistance, and their interactions. (E) Portal vein pressure: an increasing trend over time (P = 0.07) was observed, but there was no difference between LC and non‐LC livers. (F) Portal vein flow (mL/minute): portal flow increased over time (P = 0.13), with LC livers having a slightly higher increment in flow (P = 0.12), after adjusting for pressure and resistance. (G) Glucose levels (mmol/L): glucose levels decreased significantly over time (P = 0.006) and LC livers appear to have lower levels compared with non‐LC livers. (H) Hematocrit: hematocrit demonstrated a significant reduction over time (P < 0.001) with LC livers showing a gentler decreasing trend (P = 0.01). (I) Oxygen extraction ratio: the levels were found not to change significantly over time, but on average, LC livers were 0.2 units lower than non‐LC livers (P = 0.07). (J) Oxygen consumption (mL/minute/g): a significant increase in oxygen consumption mass over time was observed (P < 0.001); however, there appears to be no difference between LC and non‐LC livers.