Table 5.

Histological Features on Liver Biopsies

	Non‐LC						LC
Perfusion number	1	2	3	4	5	6	1 *	2	3	4	5	6 * , §
Large‐droplet steatosis, % †	5	5	<5	15	0	0	0	0	0	0	0	<1
Small‐droplet steatosis, % ††	90	30	<5	40	0	0	5	10	0	0	0	10
Glycogen depletion, % § (pre/post NMP)	30/90	75/90	99/80	90/80	—	5/10	80/15	—	5/5	85/75	40/30	95/10
Detached hepatocytes, % || (pre‐NMP/post‐NMP)	0/1	4/30	0/40	20/15	—	0/5	0/1	—/0	0/0	10/10	0/5	1/2
Bile duct injury ¶ (pre‐NMP/post‐NMP)	0/2	0/2	0/1	0/0	—	0/1	0/1	—/0	0/0	0/1	0/0	0/0
Coagulative necrosis, % # (pre‐NMP/post‐NMP)	0/1	0/0	0/0	0/5	—	0/10	0/0	—/0	0/0	0/2	0/10	0/5
Other findings	Microthrombi	Mild portal hepatitis		Patchy congestion	Hepatitis with severe cholestasis	Mild portal edema with eosinophils		l‐2 week‐old lytic zone 3 necrosis
Time of 2nd biopsy (hours)	6	3.2	6	6	6	6	4.5	6	6		6	5

Values designated with “—” are missing.

^*

Designates livers that were transplanted.

^†

Large‐droplet macrovesicular steatosis is defined as a single large fat droplet within the hepatocyte cytoplasm displacing the nucleus; values are % of hepatocytes containing fat.

^††

Small‐droplet macrovesicular steatosis is defined as fat droplets, usually multiple, within the cytoplasm of the hepatocyte that do not displace the nucleus; values are % of hepatocytes containing fat.

^§

Glycogen depletion is graded as the % of hepatocytes that do not contain glycogen.

^||

Detached hepatocytes is the % of hepatocytes that have lost cohesion from each other and from the sinusoidal lining.

^¶

Bile duct injury is defined as apoptotic debris within the wall or lumen or loss of cohesion between the epithelium and basement membrane; it is graded as 0 (nil), 1 (minimal), and 2 (present).

^#

Necrosis is depicted as the percent of total hepatocytes in the biopsy that shows classical ischemic‐type coagulative necrosis.