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. 2019 Jul 19;10:818. doi: 10.3389/fphar.2019.00818

Figure 6.

Figure 6

Carmofur reduced LPS-induced protein overexpression of inflammatory factors in lungs. (A) Representative immunohistochemical analyses of IL-1β, IL-6, and TNF-α in lung sections of sham mice, and ALI mice treated with vehicle (5% PEG/5% Tween-80 in saline, orally), carmofur (3 and 10 mg/kg, orally), SR144528 (2 mg/kg, i.p.), and MK886 (2 mg/kg, i.p.) sacrificed 3 days after LPS instillation. The images represent at least 75% of whole sections. Original magnification × 40; insets, × 100; scale bar, 250 µm. (B) Semiquantitative analysis of the immunohistochemical IL-1β, IL-6, and TNF-α expression. Results are expressed as mean ± SEM (n = 8 mice per group). ***P < 0.001 vs. sham. # P < 0.05; ## P < 0.01; ### P < 0.001 vs. LPS + vehicle. & P < 0.05; && P < 0.01; &&& P < 0.001 vs. LPS + carmofur (10 µM) by one-way ANOVA test.