Table 3 –
Undiscounted within - trial total costs and total QALYs as well as differences for conventional vs. intensive blood glucose control estimated from the UKPDS 72 [14] and other modeling groups.
| Simulation outcomes |
UKPDS 72 |
Participating modeling groups |
||||||
|---|---|---|---|---|---|---|---|---|
| Cardiff model |
ECHO- T2DM |
MDM- TTM |
MICADO | IQVIA- CDM |
UKPDS-OM version 1 |
UKPDS-OM version 2 |
||
| Total costs* | ||||||||
| Conventional | 26,516 | 26,996 | 14,806 | 13,094 | 13,288 | 34,523 | 21,154 | 19,428 |
| Intensive | 27,865 | 28,936 | 16,733 | 13,529 | 14,366 | 32,986 | 23,121 | 21,689 |
| Differences in total cost | 1,349 | 1,940 | 1,927 | 435 | 1,078 | −1,537 | 1,967 | 2,261 |
| Within-trial QALYs | ||||||||
| Conventional | 7.62 | 7.64 | 7.96 | 6.94 | NR | 7.27 | NR | NR |
| Intensive | 7.72 | 7.67 | 7.99 | 6.96 | NR | 7.32 | NR | NR |
| Differences in within-trial QALYs | 0.10 | 0.03 | 0.03 | 0.02 | NR | 0.05 | NR | NR |
| Total QALYs | ||||||||
| Conventional | 16.35 | 17.23 | 15.94 | 16.75 | 9.22 | 18.13 | 16.59 | 19.14 |
| Intensive | 16.62 | 17.47 | 16.11 | 16.94 | 9.50 | 18.45 | 16.79 | 19.29 |
| Differences in total QALYs | 0.27 | 0.24 | 1.17 | 0.19 | 0.28 | 0.32 | 0.20 | 0.15 |
ECHO, Economics and Health Outcomes Model of T2DM; MDM-TTM, Medical Decision Modeling Inc.—Treatment Transitions Model; MICADO, Modelling Integrated Care for Diabetes based on Observational data; NR, not reported; QALY, quality-adjusted life-year; IQVIA-CDM, IQVIA-CORE Diabetes Model; T2DM, type 2 diabetes mellitus; UKPDS, UK Prospective Diabetes Study; UKPDS-OM, UKPDS Outcomes Model.
*
Costs are presented in 2004 British pounds.