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. 2019 Jul 19;9:640. doi: 10.3389/fonc.2019.00640

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Copyright © 2019 Patel, Norman, Chang, Abedi, Liu, Chwa, Atilano, Thaker, Lu, Jazwinski, Miceli, Udar, Bota and Kenney.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic showing the changes in gene expression levels for H and J cybrids after cisplatin treatment fall into different categories: (1) there are no differences in the expression levels between the untreated and cisplatin-treated cybrids (MAPK8, MAPK10, FOXM1, BBC3, BCL2L13, CASP9, ALK1, BRCA1, EGFR, ERBB2, ERCC1, CDK2, TP53, BMI1, and KAT5/TIP60). (2) Lower expression levels of SFRP1 are found in the cisplatin-treated-J cybrid compared to the untreated-J cybrid; (3) Upregulation of CYP51A, BAX, and CASP3 in the cisplatin-treated-J cybrids compared to the untreated-J cybrids; (4) Higher levels of CDKN1A/P21 are found in the cisplatin-treated H cybrids compared to the untreated H cybrids; (5) The H-cisplatin cybrids showed higher expression levels of DHRS2/HEP2, ABCC1, and EFEMP1 compared to the cisplatin-treated-J cybrids.