Table 4.
Proportional hazards regression model for the association of different treatments with overall survival and prostate cancer-specific mortality stratified by Gleason score, age, and PSA level.
| Covariate | Cox proportional hazards regression overall survival | Competing risk regression prostate cancer-specific mortality | ||||||
|---|---|---|---|---|---|---|---|---|
| Unweighted | Weighted | Unweighted | Weighted | |||||
| Survival, HR (95% CI) | P-value | Survival, HR (95% CI) | P-value | Survival, SHR (95% CI) | P-value | Survival, SHR (95% CI) | P-value | |
| aAge ≤ 70 years old | ||||||||
| RP | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| EBRT | 3.10 (2.21–4.34) | <0.001 | 3.65 (2.58–5.16) | <0.001 | 3.15 (1.87–5.31) | <0.001 | 3.12 (1.87–5.18) | <0.001 |
| EBRT+BT | 1.90 (1.15–3.14) | 0.012 | 2.35 (1.24–4.45) | 0.009 | 1.65 (0.70–3.90) | 0.25 | 1.63 (0.69–3.86) | 0.266 |
| aAge > 70 years old | ||||||||
| RP | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| EBRT | 3.17 (2.17–4.63) | <0.001 | 3.07 (1.82–5.17) | <0.001 | 2.29 (1.31–3.99) | 0.004 | 1.94 (0.87–4.32) | 0.105 |
| EBRT+BT | 1.86 (1.10–3.13) | 0.02 | 1.84 (0.95–3.57) | 0.071 | 1.04 (0.42–2.59) | 0.934 | 0.98 (0.30–3.15) | 0.97 |
| bPSA ≤ 2.5 ng/ml | ||||||||
| RP | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| EBRT | 2.28 (0.84–6.21) | 0.106 | 4.00 (1.44–11.13) | 0.008 | 2.45 (0.71–8.42) | 0.154 | 5.13 (1.34–19.65) | 0.017 |
| EBRT+BT | 0.71 (0.76–6.68) | 0.765 | 0.58 (0.09–3.61) | 0.556 | 1.01 (0.18–5.53) | 0.993 | 1.27 (0.25–6.59) | 0.774 |
| bPSA 2.5–4 ng/ml | ||||||||
| RP | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| EBRT | 2.91 (1.46–5.80) | 0.002 | 2.89 (1.50–5.55) | 0.001 | 4.94 (1.76–13.86) | 0.002 | 9.94 (1.51–65.50) | 0.017 |
| EBRT+BT | 2.49 (0.89–6.96) | 0.081 | 4.33 (1.26–14.8) | 0.02 | 4.56 (0.92–22.58) | 0.063 | 7.29 (0.58–92.03) | 0.125 |
| bPSA > 4 ng/ml | ||||||||
| RP | 1 (Reference) | 1 (Reference) | 1 (Reference) | 1 (Reference) | ||||
| EBRT | 3.70 (2.52–5.43) | <0.001 | 3.48 (2.40–5.06) | <0.001 | 2.65 (1.74–4.04) | <0.001 | 2.19 (1.21–3.97) | 0.01 |
| EBRT+BT | 2.00 (1.21–3.30) | 0.007 | 2.02 (1.22–3.35) | 0.007 | 1.63 (0.84–3.15) | 0.14 | 1.22 (0.51–2.89) | 0.657 |
a
The multivariate Cox regression and competing risk regression derived-hazard ratios are adjusted for marital status, race, Gleason score, disease stage, and PSA level.
b
The multivariate Cox regression and competing risk regression derived-hazard ratios are adjusted for age at diagnosis, marital status, race, Gleason score, and disease stage.