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. 2019 Jul 19;10:1495. doi: 10.3389/fimmu.2019.01495

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Copyright © 2019 Chapman, Corridoni, Shiraishi, Pandey, Aulicino, Wigfield, do Carmo Costa, Thézénas, Paulson, Fischer, Kessler and Simmons.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ataxin-3 is required for ROS production and bacterial killing. (A) FACS analysis of Mitosox to quantify mROS; n = 3 Student's paired t-test, *p < 0.05. (B) FACS analysis of Mitosox of DHR to quantify total cellular ROS in control and ataxin-3 shRNA THP-1 cells. n = 7, Student's paired t-test, **p < 0.01. (C) Mitosox to quantify mROS in control and ataxin-3 shRNA THP-1 cells either left unstimulated or following stimulation for 6 h with MDP + PAM₃CSK₄; n = 4, Student's paired t-test, *p < 0.05. (D) Gentamicin survival assay of Salmonella Typhimurium infected ataxin-3 shRNA THP-1 cells compared to control. n = 3, one way ANOVA, **p < 0.01.