Table 3.

Isatuximab PK parameters

	Isatuximab (plasma)
	5 mg/kg QW/Q2W	10 mg/kg QW/Q2W	20 mg/kg QW/Q2W
Cycle 1
n	5	18	6
Cmax, mean ± SD (geometric mean) [CV%], µg/mL	91.3 ± 19.8 (89.7) [21.7]	141 ± 18.8 (140) [13.3]	297 ± 16.7 (296) [5.6]
tmax, median (min-max), h	2.42 (2.13-3.83)	3.41 (2.30-28.00)	5.22 (4.28-8.93)
AUC1week, mean ± SD (geometric mean) [CV%], μg·h/mL	6100 ± 2840 (5580) [46.5]	12 800 ± 2430* (12 600) [18.9]	27 000 ± 5620 (26 500) [20.8]
Cycle 3
n	6	24	6
Cmax, mean ± SD (geometric mean) [CV%], µg/mL	167 ± 34.5 (164) [20.6]	403 ± 163 (375) [40.4]	648 ± 246 (611) [38.0]
tmax, median (min-max), h	5.97 (1.83-7.25)	6.36 (2.00-23.67)	7.52 (4.25-48.17)
AUC2weeks, mean ± SD (geometric mean) [CV%], μg·h/mL	30 900 ± 10 900 (29 000) [35.2]	71 000 ± 34 600† (63 990) [48.7]	156 000 ± 91 000‡ (134 000) [58.5]

C_max, peak serum concentration; SD, standard deviation; t_max, time when peak serum concentration is reached. See Table 1 for expansion of other abbreviations.

^*n = 16.

^†n = 19.

^‡n = 5.