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. 2019 Jul 26;9:10845. doi: 10.1038/s41598-019-46926-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Schematic representation of tumor containing drug-sensitive (green circles) and drug-resistant cells (red circles) is shown at the center. For the sake of conceptual visualization, we have shown different samples taken from the tumor, each characterized by the same number of total cells (here N₀ = 10) but different number of M-cells, and thus different values for p₀ = M/N₀.