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. 2019 Jul 26;10:3350. doi: 10.1038/s41467-019-11266-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — ScRNA-Seq analysis of foetal and adult human liver. a Overview of foetal and adult liver FACS strategy. b 2D t-SNE visualisation of single cells isolated from foetal and adult human liver coloured by FACS gating population, shaped by tissue source. c Transcript expression of selected markers overlaid on the 2D t-SNE space of human liver scRNA-seq analysis. Expression is Log10(TPM). d Heat maps of selected gene expression in mature hepatic, foetal hepatic, hybrid hepatobiliary progenitor (HHyP) and mature cholangiocyte cell populations. Gene expression in Log10(TPM). Mean gene expression of cells in each cluster is plotted, HHyP population = 138 cells, mature biliary epithelial cell (BEC) = 9 cells, mature hepatocytes = 226 cells, foetal hepatocytes = 82 cells. e 2D t-SNE visualisation of single cells isolated from foetal and adult human liver coloured by cell type. Phenotypic labelling based on transcriptional analysis. f Proportions of tissue sample contributions from adult liver (AL) and foetal Liver (FL) in each phenotypically labelled cell type as a percentage of the total population. t-SNE t-distributed stochastic neighbour embedding, TPM transcripts per million, FACS fluorescence-activated cell sorting