Table 2.
Antibody response to FliC and association with SGG Gallo2178 and Gallo2179 antibody positivity.
| FliC quartile | Gallo2178 | p-valueb | Gallo2179 | p-valueb | ||
|---|---|---|---|---|---|---|
| neg n (%) | pos n (%) | neg n (%) | pos n (%) | |||
| Nijmegen/Detroit studies | ||||||
| Total | 150 (100) | 17 (100) | 151 (100) | 16 (100) | ||
| Q1 | 36 (24) | 2 (12) | 35 (23) | 3 (19) | ||
| Q2 | 27 (18) | 2 (12) | 28 (19) | 1 (6) | ||
| Q3 | 29 (19) | 8 (47) | 29 (19) | 8 (50) | ||
| Q4 | 58 (39) | 5 (29) | 0.072 | 59 (39) | 4 (25) | 0.040 |
| Controls | 65 (100) | 9 (100) | 66 (100) | 8 (100) | ||
| Q1 | 17 (26) | 2 (22) | 16 (24) | 3 (38) | ||
| Q2 | 18 (28) | 1 (11) | 18 (27) | 1 (13) | ||
| Q3 | 14 (22) | 3 (33) | 14 (21) | 3 (38) | ||
| Q4 | 16 (25) | 3 (33) | 0.658 | 18 (27) | 1 (13) | 0.471 |
| Cases a | 85 (100) | 8 (100) | 85 (100) | 8 (100) | ||
| Q1 | 19 (22) | 0 (0) | 19 (22) | 0 (0) | ||
| Q2 | 9 (11) | 1 (13) | 10 (12) | 0 (0) | ||
| Q3 | 15 (18) | 5 (63) | 15 (18) | 5 (63) | ||
| Q4 | 42 (49) | 2 (25) | 0.023 | 41 (48) | 3 (37) | 0.021 |
| MCC-Spain | ||||||
| Total | 1012 (100) | 140 (100) | 1015 (100) | 137 (100) | ||
| Q1 | 268 (26) | 28 (20) | 269 (27) | 27 (20) | ||
| Q2 | 226 (22) | 28 (20) | 225 (22) | 29 (21) | ||
| Q3 | 247 (24) | 41 (29) | 250 (25) | 38 (28) | ||
| Q4 | 271 (27) | 43 (31) | 0.242 | 271 (27) | 43 (31) | 0.300 |
| Controls | 519 (100) | 57 (100) | 520 (100) | 56 (100) | ||
| Q1 | 130 (25) | 15 (26) | 135 (26) | 10 (18) | ||
| Q2 | 126 (24) | 17 (30) | 127 (24) | 16 (29) | ||
| Q3 | 132 (25) | 12 (21) | 126 (24) | 18 (32) | ||
| Q4 | 131 (25) | 13 (23) | 0.757 | 132 (25) | 12 (21) | 0.354 |
| Cases a | 493 (100) | 83 (100) | 495 (100) | 81 (100) | ||
| Q1 | 138 (28) | 13 (16) | 134 (27) | 17 (21) | ||
| Q2 | 100 (20) | 11 (13) | 98 (20) | 13 (16) | ||
| Q3 | 115 (23) | 29 (35) | 124 (25) | 20 (25) | ||
| Q4 | 140 (28) | 30 (36) | 0.011 | 139 (28) | 31 (38) | 0.268 |
aCases include n = 23 adenoma and n = 70 CRC cases for Nijmegen/Detroit studies, all cases were CRC in MCC Spain; bChi-Square test; significant associations (p-value < 0.05) are marked in bold font.