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. 2019 Jul 26;9:10870. doi: 10.1038/s41598-019-47310-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Accumulation of CXCR3⁺ T cells in the synovial fluid of patients with PsA. Mononuclear cells were isolated from peripheral blood and synovial fluids of patients with PsA and evaluated by flow cytometry. (A) PBMCs (PB) and SFMCs (SF) from three PsA patients were analyzed for the expression of chemokine receptor CXCR3 on total memory CD45RA⁻ CD8⁺ cells. Statistical analysis of the differences was performed by Student’s t-test for paired samples. p values < 0.05 were considered significant: *p < 0.05. Density plot from one representative patient with PsA analyzed for the expression of chemokine receptors CCR6 and CXCR3 in CD8⁺ CD45RA⁻ T cells is also shown in the panel. (B) PBMCs and SFMCs from three PsA patients were analyzed for the expression of chemokine receptor CCR4, CXCR3 in the CD4⁺CD45RA⁻ cell subsets, left side of the panel. Statistical analysis of the differences was performed by Student’s t-test for paired samples. p values < 0.05 were considered significant: *p < 0.05, **p < 0.01. One representative dot plot experiment is also shown in the panel, the axis scales are reported as log. CXCL10 concentration in serum (S) and paired synovial fluid (SF) samples from PsA patients is shown on the right side of panel. (C) PBMCs and SFMCs from three PsA patients were analyzed for the expression of CD69 activation marker on total memory CD45RA⁻ CD8⁺ from paired PBMCs and SFMCs. Statistical analysis of the differences was performed by Student’s t-test for paired samples. p values < 0.05 were considered significant: *p < 0.05. One representative dot plot analysis of CD69 expression on CD45RA⁻ CD8⁺ and CD4⁺ gated T cells from paired PBMCs and SFMCs is also shown in the panel, the axis scales are reported as log.